MTGR1 Antibody (2C10) Summary
| Immunogen |
CBFA2T2 (NP_001028171, 201 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
|
| Specificity |
CBFA2T2 – core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (2C10)
|
| Isotype |
IgG2b Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CBFA2T2
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for MTGR1 Antibody (2C10)
- core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- EHTDKFZp313F2116
- ETO homolog on chromosome 20
- ETO homologous on chromosome 20
- MTG8-like protein
- MTG8-related protein 1
- MTGR1p85
- myeloid translocation gene-related protein 1
- Myeloid translocation-related protein 1
- protein CBFA2T2
- ZMYND3
Background
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5-region of the RUNX1 (AML1) gene fused to the 3-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq]