RASGRP 4 Antibody (1F3) Summary
| Immunogen |
RASGRP4 (NP_733748, 574 a.a. ~ 674 a.a) partial recombinant protein with GST tag.CGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
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| Specificity |
RASGRP4 – RAS guanyl releasing protein 4
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| Isotype |
IgG2a Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
RASGRP4
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactive against recombinant protein for Western Blot. Has also been used for immunohistochemistry (paraffin) and ELISA.
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| Publications |
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Reactivity Notes
Human. Other species not tested.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
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Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for RASGRP 4 Antibody (1F3)
- guanyl nucleotide releasing protein 4
- RAS guanyl releasing protein 4
- RAS guanyl-releasing protein 4
Background
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development.