FKBP12 Antibody (1E5-A12) Summary
| Immunogen |
FKBP1A (AAH05147, 1 a.a. – 108 a.a.) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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| Specificity |
FKBP1A – FK506 binding protein 1A, 12kDa
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
FKBP1A
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
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Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for FKBP12 Antibody (1E5-A12)
- 12 kDa FKBP
- EC 5.2.1.8
- FK506 binding protein 1A, 12kDa
- FK506-binding protein 1A
- FKBP1
- FKBP12
- FKBP12C
- FKBP12FKBP12-Exip3
- FKBP-12T-cell, 12-kD
- FKBP1a
- FKBP-1A
- peptidyl-prolyl cis-trans isomerase FKBP1A
- PKC12
- PPIase FKBP1A
- PPIASE
- protein kinase C inhibitor 2
- rotamase
Background
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. There is evidence of multiple alternatively spliced transcript variants for this gene, but the full length nature of some variants has not been determined.