Tripeptidyl-Peptidase I/TPP1 Antibody (3B1) Summary
| Immunogen |
TPP1 (AAH14863 195 a.a. – 304 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPF
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| Specificity |
TPP1 – tripeptidyl peptidase I
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
TPP1
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P and ELISA.
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
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Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Tripeptidyl-Peptidase I/TPP1 Antibody (3B1)
- Cell growth-inhibiting gene 1 protein
- ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease)
- CLN2
- CLN2EC 3.4.14.9
- growth-inhibiting protein 1
- LINCL
- LPIC
- lysosomal pepstatin insensitive protease
- Lysosomal pepstatin-insensitive protease
- MGC21297
- TPP1
- TPP-1
- TPP-I
- Tripeptidyl aminopeptidase
- tripeptidyl peptidase I
- tripeptidyl-peptidase 1
- TripeptidylPeptidase I
- Tripeptidyl-Peptidase I
Background
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.