MTGR1 Antibody Summary
| Immunogen |
CBFA2T2 (NP_001034798.1, 1 a.a. ~ 575 a.a) full-length human protein.
|
| Clonality |
Polyclonal
|
| Host |
Mouse
|
| Gene |
CBFA2T2
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This antibody is useful for Western Blot, Immunofluorescence
|
Reactivity Notes
This product is reactive against Human.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
Protein G purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for MTGR1 Antibody
- core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- EHTDKFZp313F2116
- ETO homolog on chromosome 20
- ETO homologous on chromosome 20
- MTG8-like protein
- MTG8-related protein 1
- MTGR1p85
- myeloid translocation gene-related protein 1
- Myeloid translocation-related protein 1
- protein CBFA2T2
- ZMYND3
Background
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5-region of the RUNX1 (AML1) gene fused to the 3-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.