ARFIP2 Antibody (2B5) Summary
| Immunogen |
ARFIP2 (AAH00392, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag.MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQL
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| Localization |
Cytoplasmic
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| Specificity |
ARFIP2 – ADP-ribosylation factor interacting protein 2 (arfaptin 2)
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| Isotype |
IgG2b Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
ARFIP2
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.
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| Publications |
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Reactivity Notes
Human. Other species not tested.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
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Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for ARFIP2 Antibody (2B5)
- ADP-ribosylation factor interacting protein 2
- ADP-ribosylation factor-interacting protein 2
- arfaptin 2
- arfaptin-2
- Partner of RAC1
- POR1partner of RAC1 (arfaptin 2)
- Protein POR1
Background
ARFIP2 is a ubiquitously expressed protein implicated in mediating cross talk between RAC and ARF small GTPases. It has been shown that ARFIP2 binds specifically to GTP-bound ARF1 and ARF6, but binds to Rac-GTP and Rac-GDP with similar affinities. The X-ray structure of arfaptin reveals an elongated, crescent-shaped dimer of 3-helix coiled-coils. Structures of arfaptin with Rac bound to either GDP or the slowly hydrolysable analog GMPPNP show that the switch regions adopt similar conformations in both complexes.