HTRA2/Omi Antibody (3G5) Summary
| Immunogen |
HTRA2 (AAH00096, 359 a.a. ~ 458 a.a) partial recombinant protein with GST tag.RRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
|
| Localization |
Mitochondrial, predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase 8 truncated BID/tBID.
|
| Specificity |
HTRA2 – HtrA serine peptidase 2
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
HTRA2
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactive against cell lysate and recombinant protein for Western Blot. Has also been used for immunofluoresence and ELISA.
|
Reactivity Notes
Human. Other species not tested.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for HTRA2/Omi Antibody (3G5)
- High temperature requirement protein A2
- HtrA serine peptidase 2
- HTRA2
- HtrA-like serine protease
- Omi
- OMIOmi stress-regulated endoprotease
- PARK13EC 3.4.21.108
- PRSS25
- PRSS25serine, 25
- Serine protease 25
- serine protease HTRA2, mitochondrial
- Serine proteinase OMI
Background
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.