RAPGEF2 Antibody (1E8) Summary
| Immunogen |
RAPGEF2 (XP_376350, 1398 a.a. ~ 1488 a.a) partial recombinant protein with GST tag.PITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
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| Localization |
Associated with the synaptic plasma membrane
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| Specificity |
RAPGEF2 – Rap guanine nucleotide exchange factor (GEF) 2
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
RAPGEF2
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactive against recombinant protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.
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| Publications |
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Reactivity Notes
Human. Other species not tested.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for RAPGEF2 Antibody (1E8)
- CNrasGEF
- KIAA0313
- Neural RAP guanine nucleotide exchange protein
- nRap GEP
- NRAPGEP
- PDZ domain containing guanine nucleotide exchange factor (GEF) 1
- PDZGEF1
- PDZ-GEF1PDZ domain-containing guanine nucleotide exchange factor 1
- RA(Ras/Rap1A-associating)-GEF
- RA-GEFDKFZP586O1422
- Rap guanine nucleotide exchange factor (GEF) 2
- rap guanine nucleotide exchange factor 2
- Rap-GEP
Background
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM]