Product: CC-402 (hydrochloride)
MCM3 Antibody (3E1.) Summary
| Immunogen |
MCM3 (NP_002379 699 a.a. – 808 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. AKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI
|
| Specificity |
MCM3 – MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) (3E1)
|
| Isotype |
IgG2b Kappa
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MCM3
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IF and ELISA.
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for MCM3 Antibody (3E1.)
- cervical cancer proto-oncogene 5
- DNA polymerase alpha holoenzyme-associated protein P1
- DNA replication factor MCM3
- DNA replication licensing factor MCM3
- EC 3.6.4.12
- HCC5
- hRlf beta subunit
- MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
- MCM3 minichromosome maintenance deficient 3
- MGC1157
- minichromosome maintenance complex component 3
- minichromosome maintenance deficient (S. cerevisiae) 3
- minichromosome maintenance deficient 3
- P1.h
- p102
- P1-MCM3
- replication licensing factor, beta subunit
- RLF subunit beta
- RLFB
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq]