Doublecortin Antibody (1G12) Summary
| Immunogen |
DCX (AAH27925, 1 a.a. – 360 a.a.) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPLSLDDSDSLGDSM
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| Marker |
Immature Neuronal Marker
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| Specificity |
DCX – doublecortex; lissencephaly, X-linked (doublecortin)
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
DCX
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against transfected lysate and recombinant protein for WB. It has also been used for IF and ELISA.
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
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Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Doublecortin Antibody (1G12)
- doublecortin
- Doublin
- FLJ51296
- Lissencephalin-X
- Lis-X
- X-linked (doublecortin)
Background
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.