Glucokinase/GCK Antibody Summary
| Immunogen |
GCK (AAH01890.1, 1 a.a. – 465 a.a.) full-length human protein. MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| Specificity |
GCK – glucokinase (hexokinase 4, maturity onset diabetes of the young 2),
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| Clonality |
Polyclonal
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| Host |
Mouse
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| Gene |
GCK
|
| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against transfected lysate and tissue lysate for WB. It has been used for ELISA. and IF.
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
|
| Purity |
Protein A purified
|
Notes
Quality control test: Antibody reactive against mammalian transfected lysate.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Glucokinase/GCK Antibody
- EC 2.7.1
- EC 2.7.1.2
- FGQTL3
- GCK
- GK
- GLK
- glucokinase (hexokinase 4)
- Glucokinase
- Hexokinase-4
- Hexokinase-D
- HHF3
- HK4
- HK4pancreatic isozyme
- HKIV
- HXKP
- LGLK
- maturity onset diabetes of the young 2
- MODY2
Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq]