PRAME Antibody Summary
| Immunogen |
PRAME (NP_006106.1, 1 a.a. ~ 509 a.a) full-length human protein.MERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPY
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| Specificity |
Reacts with preferentially expressed antigen in melanoma.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PRAME
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is reactive against transfected lysate in western blot, and as a detection antibody in ELISA.
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
Protein A purified
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Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for PRAME Antibody
- cancer/testis antigen 130
- MAPEOIP4CT130
- melanoma antigen preferentially expressed in tumors
- OIP-4
- Opa-interacting protein 4
- Opa-interacting protein OIP4
- preferentially expressed antigen in melanoma
- Preferentially expressed antigen of melanoma
Background
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq]