GABA-A R alpha 6 Antibody Summary
| Immunogen |
Peptide representing a sequence that is specific for the alpha 6-subunit of rat GABAA receptor. Peptide antigen has no homology with any other GABAA R-subunit.
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| Specificity |
Labels the ~57k alpha 6-subunit of the GABAA receptor in Western blots of rat brain extracts.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GABRA6
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| Purity |
Unpurified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
In Western blot a band at approximately 57 kDa is seen. Use in Immunohistochemistry reported in scientific literature (PMID 18509076)
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Theoretical MW |
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Positive Control |
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
Neat whole antisera
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| Preservative |
No Preservative
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| Purity |
Unpurified
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Alternate Names for GABA-A R alpha 6 Antibody
- GABA A R alpha 6
- GABA subunit A receptor alpha 6
- GABA(A) receptor subunit alpha-6
- GABAAR alpha 6
- GABAARa6
- GABRA6
- gamma-aminobutyric acid (GABA) A receptor, alpha 6
- gamma-aminobutyric acid receptor subunit alpha-6
- MGC116903
- MGC116904
Background
GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. The alpha 6 subunit is expressed in cerebellar granule cells. Though it is concentrated at synapses, it is found on extrasynaptic membranes, as well.