EMMPRIN/CD147 Antibody (8D6) – IHC-Prediluted Summary
| Immunogen |
Human T cell line Molt 13
|
| Localization |
Cell surface
|
| Specificity |
This MAb recognizes extracellular epitope 2 within the N-terminal Ig domain of human CD147. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes are important factors in cancer invasion and metastasis.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
BSG
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Hu-chromosome location: 19p13.3
Molecular weight of antigen: 35kDa (non-reduced); 40kDa (reduced) Inhibits Homotypic Aggregation, Adhesion to Matrix Proteins, and Migation through Matrigel Order Ab without BSA/Azide. Immunohistochemistry-Paraffin 0.5 – 1 ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 – 20 min followed by cooling at RT for 20 minutes. |
Packaging, Storage & Formulations
| Storage |
Store at 4C.
|
| Buffer |
10mM PBS and 0.05% BSA
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A or G purified
|
Alternate Names for EMMPRIN/CD147 Antibody (8D6) – IHC-Prediluted
- 5F7
- basigin (Ok blood group)
- Basigin
- BSG
- CD147 antigen
- CD147
- Collagenase stimulatory factor
- EMMPRIN
- EMMPRINTCSF
- Extracellular matrix metalloproteinase inducer
- Leukocyte activation antigen M6
- M6
- OK blood group antigen
- OK
- Tumor cell-derived collagenase stimulatory factor