Nbs1 Blocking Peptide Summary
| Protein/Peptide Type |
Blocking Peptide
|
| Gene |
NBN
|
Applications/Dilutions
| Application Notes |
This peptide is useful as a blocking peptide for NBP1-06609.For further blocking peptide related protocol, click here.
|
Packaging, Storage & Formulations
| Storage |
Store at -80C. Avoid freeze-thaw cycles.
|
| Buffer |
Peptide dissolved in dH2O. Contains no BSA.
|
| Preservative |
No Preservative
|
| Concentration |
1.0 mg/ml
|
Alternate Names for Nbs1 Blocking Peptide
- ATV
- AT-V1
- AT-V2
- Cell cycle regulatory protein p95
- FLJ10155
- MGC87362
- NBN
- Nbs1
- NBS1P95
- NBSNijmegen breakage syndrome protein 1
- Nibrin
- Nijmegen breakage syndrome 1 (nibrin)
- p95 protein of the MRE11/RAD50 complex
- p95
Background
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.