Plasmacytoid Dendritic Cell Assay Kit Summary
| Kit Type |
Assay Kit
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Applications/Dilutions
| Application Notes |
Plasmacytoid Dendritic Cell (pDC) Kit is validated by Flow Cytometry for identifying pDC from human whole blood, freshly isolated peripheral blood mononuclear cells (PBMC) and frozen PBMC.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
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Kit Components
| Components |
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Alternate Names for Plasmacytoid Dendritic Cell Assay Kit
- Human Plasmacytoid Dendritic Cell (pDC)
- Human Plasmacytoid Dendritic Cell
- Plasmacytoid Dendritic Cell (pDC)
Background
Plasmacytoid Dendritic Cells (pDC) are a subset of peripheral blood Dendritic Cells which play an important role in bothinnate and adaptive immune responses. pDC recognize viral components via Toll-like Receptors (TLR) including TLR7 and TLR9, andthen rapidly produce Interferon-alpha (IFNalpha) as a primary anti-viral immune response. pDC also participate in antigen presentation, animportant functional role which drives the adaptive immune response. Intense investigation has led to pDC identifi cation with a unique setof markers by fl ow cytometry. pDC are usually present in relatively low frequency in peripheral blood. Direct identifi cation of subsets of peripheralblood DCs has an advantage in analyzing changes in number or function of DC subsets during chronic viral infections or diseasedpatients, as examples.