Integrin alpha 2/CD49b Antibody (HAS-4) Summary
| Immunogen |
Human keratinocytes
|
| Localization |
Plasma membrane
|
| Marker |
Plasma Membrane Marker
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ITGA2
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
|
| Publications |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for Integrin alpha 2/CD49b Antibody (HAS-4)
- alpha-2 subunit
- CD49b antigen
- CD49b
- Integrin alpha 2
- integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
- ITGA2
- VLA 2
- VLA-2 alpha
Background
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.