TLR8 Antibody Summary
| Immunogen |
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human TLR8 protein.
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| Specificity |
This antibody is directed against human TLR8 protein. A BLAST analysis was used to suggest cross reactivity with TLR8 protein.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TLR8
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This affinity-purified antibody has been tested for use in ELISA, immunohistochemistry and western blot. Expect a band approximately 115 kDa in size corresponding – TLR8 protein by western blotting in the appropriate cell lysate or extract.
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| Agonist |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
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| Preservative |
0.01% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for TLR8 Antibody
- CD288 antigen
- CD288
- MGC119599
- MGC119600
- TLR8
- toll-like receptor 8
Background
The TLR8 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The TLR8 gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.