FoxP3 Antibody (SPM579) [DyLight 488] Summary
| Immunogen |
Full-length human FOXP3 protein
|
| Localization |
Predominantly nuclear, some cytoplasmic
|
| Specificity |
Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
FOXP3
|
| Purity |
Protein A purified
|
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Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
50mM Sodium Borate
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for FoxP3 Antibody (SPM579) [DyLight 488]
- AIID
- AIIDMGC141961
- DIETER
- forkhead box P3
- Forkhead Box Protein P3
- FoxP3
- FOXP3delta7
- immune dysregulation, polyendocrinopathy, enteropathy, X-linked
- Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked
- IPEX
- JM2
- MGC141961
- MGC141963
- PIDX
- PIDXMGC141963
- SCURFIN
- XPID
- XPIDpolyendocrinopathy, enteropathy, X-linked