Survivin Blocking Peptide Summary
| Description |
A peptide to BIRC5.
|
| Localization |
Cytoplasm and Mitochondria.
|
| Specificity |
This peptide is specific for NB 110-92717 only.
|
| Protein/Peptide Type |
Blocking Peptide
|
| Gene |
BIRC5
|
Applications/Dilutions
| Application Notes |
This peptide is useful as a blocking peptide for NB 110-92717.For further blocking peptide related protocol, click here.
|
Packaging, Storage & Formulations
| Storage |
Store at -80C. Avoid freeze-thaw cycles.
|
| Buffer |
Peptide dissolved in dH2O. Contains no BSA.
|
| Preservative |
No Preservative
|
| Concentration |
1.0 mg/ml
|
Alternate Names for Survivin Blocking Peptide
- API4 survivin variant 3 alpha
- API4
- Apoptosis inhibitor 4 baculoviral IAP repeat-containing protein 5
- Apoptosis inhibitor survivin
- baculoviral IAP repeat-containing 5
- BIRC5
- EPR-1
- IAP4
- Survivin
Background
Survivin is a structurally unique inhibitor of apoptosis (IAP) that has been linked to protection from apoptosis, control of cell division, and cellular adaptation to stress. In order for survivin to provide this cytoprotection an interaction with at least one other IAP, such as XIAP, is necessary. It has recently been shown that Survivin is phosphorylated at Ser20 by protein kinase A (PKA) in the cytosol but not in the mitochondria. This phosphorylation on Ser20 disrupts the binding of cytosolic survivin to XIAP and therefore diminishes survivins cytoprotective properties.