Product: Tamsulosin (hydrochloride)
RGS20 Antibody Pack Summary
| Immunogen |
The following antibodies are included in this RGS20 antibody bundle: Antibody to RGS20; Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 148-161Antibody to RGS20; Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 1-15 Antibody to RGS20; Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 30-48Antibody to RGS20; Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 171-189
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| Host |
Rabbit
|
| Gene |
RGS20
|
| Purity |
Unpurified
|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human and predicted to react with Mouse and Rat
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Purity |
Unpurified
|
Alternate Names for RGS20 Antibody Pack
- G(z)GAP
- Gz-GAP
- Gz-selective GTPase-activating protein
- regulator of G-protein signaling 20
- Regulator of G-protein signaling Z1
- regulator of G-protein signalling 20
- Regulator of Gz-selective protein signaling 1
- RGSZ1g(z)GAP
- ZGAP1gz-GAP
Background
RGS proteins are regulatory and structural components GPCR complexes. These are GAPs for Gi and Gq class Galpha proteins and negatively regulate GPCR signaling pathways. RGS20, a 25KDa protein, is a member of this family and is human homolog of bovine Gz-GAP. It contains an N-terminal cysteine string that is potential site for multiple palmitoylation and a C-terminal RGS core domain. RGS20 plays a vital role in regulating GPCR signals in brain, neuronal development and regulation of golgi structure. RGS20 specifically interacts and accelerates the hydrolysis of G-alphaz. Reports suggest that RGS20 interacts with G-alphai subunit and plays a significant role in regulation of G-alphai-mediated signaling. It is a membrane-bound protein specifically expressed in brain, with highest concentrations in caudate nucleus and temporal lobe.