BRCA2 Antibody Summary
| Immunogen |
This antibody is specific for the N Terminus Region of the target protein.
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| Specificity |
This product is specific for Human BRCA2.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
BRCA2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is useful in ELISA.
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| Publications |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Notes
Manufactured by SDIXs proprietary Genomic Antibody Technology™. GAT FAQs.
Alternate Names for BRCA2 Antibody
- BRCA1/BRCA2-containing complex, subunit 2
- BRCA2
- BRCC2
- breast and ovarian cancer susceptibility gene, early onset
- breast cancer 2 tumor suppressor
- breast cancer 2, early onset
- breast cancer susceptibility protein BRCA2
- breast cancer type 2 susceptibility protein
- BROVCA2
- FACD
- FAD
- FAD1
- FANCB
- FANCD
- FANCD1Fanconi anemia, complementation group D1
- Fanconi anemia group D1 protein
- GLM3
- PNCA2
Background
BRCA 2 is localized to chromosome 13q12 – q13. Loss of heterozygosity of 13q is observed in 25% of sporadic breast tumors, which indicates that BRCA 2 might be a tumor suppressor gene. BRCA 2 confers only a low ovarian cancer risk. Reportedly, in MCF-10F (normal breast epithelial cell line) and MCF-7 (breast cancer cell line) cells the expression of BRCA 2 RNA lowers in G0 and early G1 phases then gets up-regulated at the G1 / S phase junction.