Product: PF-8381 (hydrochloride)
Transgelin/TAGLN/SM22 alpha Antibody (SPM606) [HRP] Summary
| Immunogen |
Recombinant full-length human transgelin (TAGLN) protein.
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| Localization |
Cytoplasmic
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| Specificity |
This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
TAGLN
|
| Purity |
Protein A or G purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Optimal dilution of this antibody shomld be experimentally determined.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
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| Buffer |
PBS
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| Preservative |
No Preservative
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| Purity |
Protein A or G purified
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Alternate Names for Transgelin/TAGLN/SM22 alpha Antibody (SPM606) [HRP]
- DKFZp686P11128
- Protein WS3-10
- SM22 alpha
- SM2222 kDa actin-binding protein
- SMCCDKFZp686B01212
- Smooth muscle protein 22-alpha
- TAGLN
- TAGLN1
- transgelin variant 2
- Transgelin
- WS3-10
- WS3-10SM22-alpha