Product: Helioxanthin derivative 5-4-3
VEGFR1/Flt-1 Antibody (Flt-1/EWI) Summary
| Immunogen |
Recombinant human soluble Flt-1 protein
|
| Marker |
Endothelial Cell Marker
|
| Specificity |
Mouse Monoclonal to VEGFR-1 (Flt-1/EWI)
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
FLT1
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
ELISA: Use diluted 1.5?8 ug/ml IgG1. Western blotting: Use 1?10 ug/ml IgG1. Immunoprecipitation: For IP use 1-5 ug IgG1 per 1 ml lysate or reaction volume.
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
No buffer
|
| Preservative |
No Preservative
|
| Concentration |
LYOPH
|
| Purity |
Protein A purified
|
| Reconstitution Instructions |
Reconstitute with 50 ul sterilized water to desired concetration.
|
Alternate Names for VEGFR1/Flt-1 Antibody (Flt-1/EWI)
- EC 2.7.10
- EC 2.7.10.1
- FLT
- FLT1
- Flt-1
- Fms-like tyrosine kinase 1
- fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor)
- FRT
- Tyrosine-protein kinase FRT
- Tyrosine-protein kinase receptor FLT
- vascular endothelial growth factor receptor 1
- Vascular permeability factor receptor
- VEGF R1
- VEGFR1
- VEGFR-1
Background
VEGF Receptor 1 (also known as FLT) belongs to the src gene family and shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The protein acts as a receptor for VEGF, VEGFB and PGF. An alternatively spliced form of the gene produces a soluble protein (sFlt1) which binds vascular endothelial growth factor (VEGF) with high affinity. sFlt1 has a higher affinity for VEGF indicating that it may function as an inhibitor in the VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells and peripheral blood monocytes.