alpha-Synuclein Antibody Summary
| Immunogen |
The antiserum was produced against synthesized peptide derived from human Synuclein. The immunogen region is: C-terminal.
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| Specificity |
Synuclein (Ab-129) Antibody detects endogenous levels of total Synuclein protein.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
SNCA
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
14 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for alpha-Synuclein Antibody
- alpha-Synuclein
- Lewy body) 4
- MGC110988
- NACP
- non A-beta component of AD amyloid
- Non-A beta component of AD amyloid
- Non-A4 component of amyloid precursor
- non-A4 component of amyloid
- PARK1
- PARK4
- PD1
- SNCA
- synuclein, alpha (non A4 component of amyloid precursor)
- Synuclein-alpha
Background
Nitrated alpha-Synuclein may be involved in the regulation of dopamine release and transport. It is a soluble protein which is primarily localized at the presynaptic regions of axons. It can form filamentous aggregates, which are the major non amyloid component of intracellular inclusions in many neurodegenerative synucleinopathies. Nitrated alpha-Synuclein has been found to reduce neuronal responsiveness to several apoptotic stimuli which leads to a decreased caspase-3 activation.