Product: 3,3,6-Triiodo-L-thyronine (sodium)
LAT Antibody (LAT-1D1) Summary
| Immunogen |
Bacterially expressed full-length rat LAT
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| Specificity |
The antibody LAT-1D1 reacts with mouse and rat Linker for activation of T cells (LAT), a transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
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| Isotype |
IgG2a
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
LAT
|
| Purity |
Protein A purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Cross reacts with Mouse and Rat. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
15mM Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Protein A purified
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Alternate Names for LAT Antibody (LAT-1D1)
- 36 kDa phospho-tyrosine adapter protein
- LAT
- LAT1,36 kDa phospho-tyrosine adaptor protein
- linker for activation of T cells
- linker for activation of T-cells family member 1
- p36-38
- pp36
Background
LAT (linker for activation of T-cells) is involved in the T-cell antigen receptor (TCR) signal transduction pathway, and may play an important role downstream in activating protein tyrosine kinases (1). LAT is phosphorylated by ZAP-70/Syk protein tyrosine kinases leading to recruitment of multiple signaling molecules (2). It has been found that Tyr191 and Tyr171 are required for T-cell activation and Tyr132 is required for the activation of PLCgamma1 and Ras signaling pathways, respectively. Tyr226 and Tyr191 are required for Vav binding, whereas Tyr171 and Tyr132 are necessary for association and activation of phosphoinositide 3-kinase activity and PLCgamma1 (3).