EGF R/ErbB1 [p Tyr992] Antibody (EM-12) Summary
| Immunogen |
Synthetic phospho-peptide covering sequence around tyrosine 992 of human EGFR.
|
| Modification |
p Tyr992
|
| Specificity |
The antibody EM-12 reacts with human EGFR (ErbB1 / HER1) phosphorylated on tyrosine 992.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
EGFR
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for EGF R/ErbB1 [p Tyr992] Antibody (EM-12)
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- cell growth inhibiting protein 40
- cell proliferation-inducing protein 61
- EC 2.7.10
- EC 2.7.10.1
- EGF R
- EGFR
- epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog)
- epidermal growth factor receptor
- ErbB
- ErbB1
- ERBB1PIG61
- HER1
- HER-1
- mENA
- Proto-oncogene c-ErbB-1
- Receptor tyrosine-protein kinase erbB-1
Background
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR over expression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.