PRR7 Antibody (TRAP3/10) Summary
| Immunogen |
Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)
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| Specificity |
The mouse monoclonal antibody TRAP3/10 recognizes an epitope located in the C-terminal part of the intracellular domain of PRR7/TRAP3 (amino acids 126-253 of human PRR7 / TRAP3), a 28 kDa proline-rich membrane protein presumably associated with NMDA receptor complex.
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| Isotype |
IgG2a
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
PRR7
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Immunocytochemistry: Cell culture fixed with 4% paraformaldehyde, permeabilized with 0.1% Triton-X100
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Reactivity Notes
Cross reacts with Human, Mouse and Rat. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
15mM Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Protein A purified
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Alternate Names for PRR7 Antibody (TRAP3/10)
- MGC10772
- proline rich 7 (synaptic)
- proline-rich protein 7
- Synaptic proline-rich membrane protein
Background
PRR7/TRAP3 (proline-rich 7, transmembrane adaptor protein 3) is a 28 kDa transmembrane adaptor protein ubiquitously expressed at low level (most in brain). Its amino acid sequence is extremely conserved among mammalian and other species. PRR7/TRAP3 contains potential palmitoylation motif and is found in lipid rafts. It is a part of the complex postsynaptic density fraction in neurons and associates with PSD-95, NMDA receptor and probably other proteins. The intracellular domain of PRR7/TRAP3 contains several tyrosines, a proline-rich sequence, and a C-terminal PDZ-binding motif. So far nothing is known about function of this protein. It may be involved in regulation of some receptor signaling and in formation of neurologic and immunologic synapse.