CD1a Antibody (HI149) Summary
| Immunogen |
Human thymocytes
|
| Localization |
Type I membrane protein
|
| Specificity |
The antibody HI149 reacts with CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes. HLDA V; WS Code CD01.01
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CD1A
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for CD1a Antibody (HI149)
- CD1
- CD1a antigen
- CD1A antigen, a polypeptide
- CD1a molecule
- CD1a
- cluster of differentiation 1 A
- cortical thymocyte antigen CD1A
- differentiation antigen CD1-alpha-3
- epidermal dendritic cell marker CD1a
- FCB6
- hTa1 thymocyte antigen
- HTA1
- R4
- T6
- T-cell surface antigen T6/Leu-6
- T-cell surface glycoprotein CD1a
Background
CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.