FPR1 Antibody

Product: Lucigenin

FPR1 Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from 2nd extracellular domain of human FPR1.
Localization
Cell Membrane
Specificity
Human FPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Clonality
Polyclonal
Host
Rabbit
Gene
FPR1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 2 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Chimpanzee (94%), Gorilla (94%), Orangutan (88%), Gibbon (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for FPR1 Antibody

  • fMet-Leu-Phe receptor
  • fMLF-R
  • fMLP receptor
  • FMLP
  • formyl peptide receptor 1
  • FPR1
  • FPRfMet-Leu-Phe receptor
  • N-formyl peptide receptor
  • N-formylpeptide chemoattractant receptor

Background

Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract polymorphonuclear neutrophils to sites of infection. FPR receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FPR receptor may be able to inhibit HIV infection. (WO0157074) FPR1 has been reported in blood monocytes, neutrophils, and phagocytes, as well as in liver, astrocytes, and microglia. ESTs have been isolated from B-cell/lung/testis, blood, brain, eye, heart, liver/spleen, kidney, lung, pancreas, placenta, spleen, and uterus libraries.

PMID: 25205655