Product: Bucladesine (calcium salt)
GPR37 Antibody Summary
| Immunogen |
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37.
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| Specificity |
Human GPR37. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Predicted Species |
Monkey (95%), Primate (90%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GPR37
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (95%), Marmoset (90%), Rabbit (85%), Panda (80%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for GPR37 Antibody
- EDNRBL
- Endothelin B receptor-like protein 1
- ETBR-LP-1
- G protein-coupled receptor 37 (endothelin receptor type B-like)
- GPR37
- hET(B)R-LP
- PAELR
- PAELRETBR-LP-1
- Parkin-associated endothelin receptor-like receptor
- probable G-protein coupled receptor 37
Background
GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinsons (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. GPR37 expression has been reported in brain, liver, and placenta. ESTs have been isolated from brain, embryo, eye, fetal lung/testis/Bcell, gallbladder, heart, liver, liver/spleen, melanocyte/uterus/fetal heart, nerve, placenta, testis, tonsil, and vessel libraries.