AHR Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from C-terminus of human Aryl Hydrocarbon Receptor.
|
| Epitope |
C-terminal region of human.
|
| Specificity |
Human Aryl Hydrocarbon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TCHHL1 (56%).
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
AHR
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||
| Positive Control |
|
||
| Reviewed Applications |
|
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Monkey (88%), Bat (88%), Elephant (88%), Guinea Pig (88%), Marmoset (81%), Bovine (81%), Hamster (81%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for AHR Antibody
- Ah receptor
- AHR
- AH-receptor
- aryl hydrocarbon receptor
- BHLHE76
- bHLHe76aromatic hydrocarbon receptor
- Class E basic helix-loop-helix protein 76
Background
The Aryl Hydrocarbon Receptor (AHR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AH Receptor. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AHR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AHR followed by formation of a heterodimer with AHR nuclear translocator protein (Arnt). The AHR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.