Product: UNC0380 (trifluoroacetate)
CCR7 Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from 1st extracellular domain of human CCR7.
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| Specificity |
Human CCR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR141 (44%).
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| Predicted Species |
Porcine (94%), Bovine (94%), Monkey (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CCR7
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB usage is reported in scientific literature (PMID: 25225162).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (88%), Elephant (88%), Bat (88%), Equine (88%), Rabbit (88%), Panda (81%), Canine (81%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CCR7 Antibody
- BLR2C-C chemokine receptor type 7
- C-C CKR-7
- CC-CKR-7
- CCR7
- CCR-7
- CD197 antigen
- CD197
- CDw197CC chemokine receptor 7
- chemokine (C-C motif) receptor 7
- CMKBR7chemokine (C-C) receptor 7
- EBI1EBV-induced G protein-coupled receptor 1
- EBV-induced G-protein coupled receptor 1
- Epstein-Barr virus induced gene 1
- Epstein-Barr virus induced G-protein coupled receptor
- Epstein-Barr virus-induced G-protein coupled receptor 1
- EVI1
- lymphocyte-specific G protein-coupled peptide receptor
- MIP-3 beta receptor
Background
CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naive T cells. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. This receptor is particularly expressed in lymphoid tissues and in activated B and T lymphocytes. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries.