P2Y12/P2RY12 Antibody Summary
| Immunogen |
Synthetic 17 amino acid peptide from N-terminal extracellular domain of human P2RY12 / P2Y12.
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| Epitope |
N-terminal extracellular
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| Specificity |
Human P2RY12 / P2Y12. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Predicted Species |
Monkey (94%), Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
P2RY12
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (88%), Marmoset (88%), Porcine (82%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
|
Alternate Names for P2Y12/P2RY12 Antibody
- ADPG-R
- Gi-coupled ADP receptor HORK3
- HORK3
- HORK3P2Y12 platelet ADP receptor
- P2RY12
- P2T(AC)
- P2Y purinoceptor 12
- P2Y(AC)
- P2Y(ADP)
- P2Y(cyc)
- P2Y12
- P2Y12ADP-glucose receptor
- purinergic receptor P2RY12
- purinergic receptor P2Y, G-protein coupled, 12
- putative G-protein coupled receptor
- SP1999
- SP1999G-protein coupled receptor SP1999
Background
P2Y12 is a Purinergic Receptor essential for the aggregation of blood platelets. There is evidence that mutations in P2Y12 cause a bleeding disorder, suggesting that knowledge of the P2Y12 receptor could advance the development of antiplatelet agents to treat cardiovascular diseases. Expression of P2Y12 has been reported in platelets, spinal cord, and many brain regions. ESTs for P2Y12 have been isolated from B-cell/lung/testis, brain, embryo, prostate, eye, kidney carcinoma, and colon carcinoma libraries. Cognate