HSF1 Antibody (10H8) Summary
| Immunogen |
Recombinant mouse HSF1.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
HSF1
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This antibody is useful in Immunohistochemistry (paraffin sections). Predicted MW of ~60kDa. Detects a band of ~85kDa by Western blot.
|
Reactivity Notes
Human, Mouse, Rat, Primate and Rabbit.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS and 50% Glycerol
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein G purified
|
Alternate Names for HSF1 Antibody (10H8)
- heat shock factor protein 1
- heat shock transcription factor 1HSTF1HSF 1
- HSF1
- HSTF 1
- HSTF1
Background
HSFs (Heat Shock family of transcription factors), which consists of HSF 1-4, bind to highly conserved Heat shock elements (HSEs) in the promoter regions of heat shock genes, ultimately regulating the expression of Heat shock proteins (Hsps). On exposure to heat shock and other stresses, HSF1 localizes within seconds to discrete nuclear granules and on recovery from stress, HSF1 rapidly dissipates from the stress granules to a diffuse nucleoplasmic distribution.