MRP6 Antibody (M6II-7) Summary
| Immunogen |
The antibody reacts with the MRP6 antigen.
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| Specificity |
M6II-7 reacts with MRP6, a 190-200 kD transmembrane protein that is related to the multidrug resistance related protein MRP. Mutations in the MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-7 was raised against a bacterial fusion protein of human MRP6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein. M6II-7 did not cross-react with the human MDR1, MRP1, MRP2, MRP3, MRP4, MRP5 gene products.
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| Isotype |
IgG2 Alpha
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| Clonality |
Monoclonal
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| Host |
Rat
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| Gene |
ABCC6
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| Purity |
Tissue culture supernatant
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Applications/Dilutions
| Dilutions |
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| Application Notes |
M6II-7 can be used to detect human MRP6 in cells and tissues. Immunocytochemistry: use 1:20-50 dilution on acetone fixed cytospin preparations. For immunohistochemistry: M6II-7 (use 1:20-50) on acetone fixed frozen sections can be followed by incubation w
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
1.0% BSA
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| Preservative |
0.1% Sodium Azide
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| Purity |
Tissue culture supernatant
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Alternate Names for MRP6 Antibody (M6II-7)
- Anthracycline resistance-associated protein
- ARAPXE
- ATP-binding cassette, sub-family C (CFTR/MRP), member 6
- EST349056
- MLP1ABC34
- MOATE
- MOAT-E
- MRP6ATP-binding cassette sub-family C member 6
- multidrug resistance-associated protein 6
- Multi-specific organic anion transporter E
- pseudoxanthoma elasticum
- PXE1
- URG7
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.