Dishevelled-3 Antibody Summary
| Immunogen |
This antibody is specific for the C Terminus Region of the target protein.
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| Specificity |
This product is specific for Human DVL3.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
DVL3
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is useful in ELISA, Western Blot and Immunohistochemistry-Paraffin.
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| Publications |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Notes
Manufactured by SDIXs proprietary Genomic Antibody Technology™. GAT FAQs.
Alternate Names for Dishevelled-3 Antibody
- dishevelled 3 (homologous to Drosophila dsh)
- dishevelled, dsh homolog 3 (Drosophila)
- Dishevelled3
- Dishevelled-3
- DSH homolog 3
- DVL3
- KIAA0208dishevelled-3
- segment polarity protein dishevelled homolog DVL-3
Background
The human DVL-3 gene encodes a predicted 716 amino acid protein which exhibits 98% amino acid identity with mouse Dsh-3 and 49% with Drosophila Dsh. Dsh-3 was mapped to 3q27. The expression of Dsh-3 mRNA was detected in 30 human cell lines and 2 primary cell cultures. Dsh-3 mRNA was detected in normal human breast tissues and tumors. Statistically, there was no difference in Dsh-3 mRNA level between normal breast tissues and tumors. In human colorectal samples, Dsh-3 was expressed equally in matched normal tissues, polyps and tumors. The data indicaes that Dsh-3 is widely expressed in human cells and may have a widespread role in signal transduction (1). Results indicate that the human dishevelled genes constitute a multigene family and that Dsh 3 proteins are highly conserved among metazoans.