Product: SBE14 (Hydrochloride)
PTP1B/PTPN1 Antibody Summary
| Immunogen |
In vivo generated recombinant protein fragment
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| Specificity |
This product is specific for Human PTPN1.
|
| Clonality |
Polyclonal
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| Host |
Rabbit
|
| Gene |
PTPN1
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| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
|
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| Application Notes |
This antibody is useful in ELISA, Immunohistochemistry-Paraffin and Western Blot.
|
|
| Publications |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
|
| Preservative |
No Preservative
|
| Purity |
Immunogen affinity purified
|
Notes
Manufactured by SDIXs proprietary Genomic Antibody Technology™. GAT FAQs.
Alternate Names for PTP1B/PTPN1 Antibody
- EC 3.1.3.48
- protein tyrosine phosphatase 1B
- protein tyrosine phosphatase, non-receptor type 1
- Protein-tyrosine phosphatase 1B
- PTP1B
- PTP-1B
- PTP1Bprotein tyrosine phosphatase, placental
- PTPN1
- tyrosine-protein phosphatase non-receptor type 1
Background
The non-transmembrane protein tyrosine phosphatase, PTP1B, comprises 435 amino acids, of which the C-terminal 114 residues have been implicated in controlling both localization and function of this enzyme. Increased phosphorylation of PTP1B is seen to accompany the transition from G2 to M phase of the cell cycle. Immunofluorescence experiments indicate that PTP-1B is localized predominantly in the endoplasmic reticulum (ER). Subcellular fractionation is consistent with this localization and establishes that PTP-1B is tightly associated with microsomal membranes, with its phosphatase domain oriented towards the cytoplasm. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation (2). It has also been shown that PTP1B is a novel substrate for Akt and that phosphorylation of PTP1B by Akt at Ser(50) may negatively modulate its phosphatase activity creating a positive feedback mechanism for insulin signaling (3).