Cortactin Antibody Summary
| Immunogen |
This antibody is specific for the Middle Region of the target protein.
|
| Specificity |
This product is specific for Human CTTN.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
CTTN
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
|
| Application Notes |
This antibody is useful in ELISA and Western Blot.
|
|
| Publications |
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
|
| Preservative |
No Preservative
|
| Purity |
Immunogen affinity purified
|
Notes
Manufactured by SDIXs proprietary Genomic Antibody Technology™. GAT FAQs.
Alternate Names for Cortactin Antibody
- 1110020L01Rik
- Amplaxin
- Cortactin
- CTTN
- ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 srcsubstrate)
- EMS1
- EMS1amplaxin
- FLJ34459
- Oncogene EMS1
- src substrate cortactin
Background
Immunocytochemistry reveals that in epithelial cells, the human cortactin protein is localized mainly in the cytoplasm and, to a very low extent, in protruding leading lamellae of the cell. However, in carcinoma cells that constitutively overexpress cortactin accumulates in the podosome-like adherens junctions associated with the cell-substratum contact sites. Overexpression and concomitant accumulation of the Cortactin protein in the cell-substratum contact sites might, therefore, contribute to the invasive potential of these tumor cells (1). In cells derived from breast carcinomas and squamous carcinomas of the head and neck, DNA amplification of a particular tyrosine kinase substrate region results in overexpression of cortactin. Overexpression is accompanied by a partial redistribution of cortactin from the cytoplasm into cell-matrix contact sites (2).