CD28 Antibody (PV-1) Summary
| Immunogen |
C57BL/6N mouse T cell lymphoma EL4 cell line
|
| Specificity |
Murine CD28
|
| Isotype |
IgG
|
| Clonality |
Monoclonal
|
| Host |
Armenian Hamster
|
| Gene |
CD28
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
0.1M BBS (pH 8.2)
|
| Preservative |
No Preservative
|
| Concentration |
0.5 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for CD28 Antibody (PV-1)
- CD28 antigen (Tp44)
- CD28 antigen
- CD28 molecule
- CD28
- MGC138290
- T-cell-specific surface glycoprotein CD28
- Tp44
Background
CD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T lymphocytes, and at very low levels on NK cells. Its expression is upregulated upon T-cell activation. (1-4) CD28 is a ligand for CD80/B7-1 and CD86/B7-2 on B cells and other antigen presenting cells, and plays an important role in the interaction between T cells and B cells. (5) CD28 is a co-stimulatory receptor involved in many, but not all, T-cell independent immune responses. (6-9)