Bu-1b Antibody (5-11G2) Summary
| Immunogen |
Bursa cells from two- to five-week-old CHA (Bu-1b) strain chickens
|
| Specificity |
Chicken Bu-1b alloantigen, Mr 70 kDa
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Chicken
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
0.1M BBS (pH 8.2)
|
| Preservative |
No Preservative
|
| Concentration |
0.5 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for Bu-1b Antibody (5-11G2)
- B6.1
- B6.2
- Bu 1b
- LOC396098
Background
Chicken Bu-1b, a product of the Bu-1b allele, is expressed on the cell surface as a disulfide-linked homodimer. In 10-week-old H.B15 and H.B2 chickens, Bu-1 is found on 85-90% of bursal cells, 2-8% of thymocytes, 15-27% of spleen cells, and 2-18% of peripheral blood cells. It is also expressed on subsets of macrophages and monocytes, but not on granulocytes, erythrocytes or thrombocytes. In chickens heterozygous for the Bu-1 alleles (Bu-1a/b), Bu-1a does not exhibit allelic exclusion. The monoclonal antibody 5-11G2 reacts with lymphoid cells from CHA and H.B14Ab strains but does not react with cells from H.B14Aa. (1-2)