P-Selectin/CD62P Antibody (AK-4) [PE] Summary
| Immunogen |
The immunogen for this antibody was CD62P.
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
SELP
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This AK-4 antibody has been tested by flow cytometric analysis of resting and thrombin-activated human platelets. This can be used at less than or equal to 1 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Protein A or G purified
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Alternate Names for P-Selectin/CD62P Antibody (AK-4) [PE]
- CD62P antigen
- CD62P
- FLJ45155
- GMP140
- GRMP
- PADGEM
- PADGEMantigen CD62)
- PSEL
- P-Selectin
- selectin P (granule membrane protein 140kDa, antigen CD62)
- SELP
Background
The AK-4 monoclonal antibody reacts with human CD62P, a 140 kDa transmembrane glycoprotein also known as P-Selectin. Upon activation, CD62P is rapidly transported from its cytoplasmic stores in the Weibel-Palade bodies of endothelial cells or the alpha-granules of platelets to the surface. CD62P initiates the adhesive interaction between endothelial cells and neutrophils and monocytes during the inflammatory reaction and is also involved in the interaction of platelets with monocytes and neutrophils.