Product Name :
Bafetinib analog, Lyn-IN-1
Description:
Bafetinib, also known as INNO-406 and NS187, is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). This agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types.
CAS:
887650-05-7
Molecular Weight:
576.62
Formula:
C30H31F3N8O
Chemical Name:
N-[3-([5,5′-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]methyl-3-(trifluoromethyl)benzamide
Smiles :
CN(C)[C@@H]1CN(CC2=CC=C(C=C2C(F)(F)F)C(=O)NC2=CC(NC3N=CC(=CN=3)C3C=NC=NC=3)=C(C)C=C2)CC1
InChiKey:
ZOPBZHLJXQAQON-VWLOTQADSA-N
InChi :
InChI=1S/C30H31F3N8O/c1-19-4-7-24(11-27(19)39-29-36-14-23(15-37-29)22-12-34-18-35-13-22)38-28(42)20-5-6-21(26(10-20)30(31,32)33)16-41-9-8-25(17-41)40(2)3/h4-7,10-15,18,25H,8-9,16-17H2,1-3H3,(H,38,42)(H,36,37,39)/t25-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.BET bromodomain inhibitor Technical Information
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Bafetinib, also known as INNO-406 and NS187, is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity.Duvelisib supplier Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML).PMID:32875980 This agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types.|Product information|CAS Number: 887650-05-7|Molecular Weight: 576.62|Formula: C30H31F3N8O|Synonym:|INNO-406|NS-187|INNO406|INNO 406|Chemical Name: N-[3-([5,5′-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]methyl-3-(trifluoromethyl)benzamide|Smiles: CN(C)[C@@H]1CN(CC2=CC=C(C=C2C(F)(F)F)C(=O)NC2=CC(NC3N=CC(=CN=3)C3C=NC=NC=3)=C(C)C=C2)CC1|InChiKey: ZOPBZHLJXQAQON-VWLOTQADSA-N|InChi: InChI=1S/C30H31F3N8O/c1-19-4-7-24(11-27(19)39-29-36-14-23(15-37-29)22-12-34-18-35-13-22)38-28(42)20-5-6-21(26(10-20)30(31,32)33)16-41-9-8-25(17-41)40(2)3/h4-7,10-15,18,25H,8-9,16-17H2,1-3H3,(H,38,42)(H,36,37,39)/t25-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|