Product Name :
Tomeglovir
Description:
Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV.
CAS:
233254-24-5
Molecular Weight:
441.54
Formula:
C23H27N3O4S
Chemical Name:
N-4-[5-(dimethylamino)naphthalene-1-sulfonamido]phenyl-3-hydroxy-2,2-dimethylpropanamide
Smiles :
CN(C)C1=CC=CC2C1=CC=CC=2S(=O)(=O)NC1C=CC(=CC=1)NC(=O)C(C)(C)CO
InChiKey:
OSQAKHSYTKBSPB-UHFFFAOYSA-N
InChi :
InChI=1S/C23H27N3O4S/c1-23(2,15-27)22(28)24-16-11-13-17(14-12-16)25-31(29,30)21-10-6-7-18-19(21)8-5-9-20(18)26(3)4/h5-14,25,27H,15H2,1-4H3,(H,24,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.BTX-A51 Biological Activity
Shelf Life:
≥12 months if stored properly.Lopinavir In stock
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV.|Product information|CAS Number: 233254-24-5|Molecular Weight: 441.54|Formula: C23H27N3O4S|Chemical Name: N-4-[5-(dimethylamino)naphthalene-1-sulfonamido]phenyl-3-hydroxy-2,2-dimethylpropanamide|Smiles: CN(C)C1=CC=CC2C1=CC=CC=2S(=O)(=O)NC1C=CC(=CC=1)NC(=O)C(C)(C)CO|InChiKey: OSQAKHSYTKBSPB-UHFFFAOYSA-N|InChi: InChI=1S/C23H27N3O4S/c1-23(2,15-27)22(28)24-16-11-13-17(14-12-16)25-31(29,30)21-10-6-7-18-19(21)8-5-9-20(18)26(3)4/h5-14,25,27H,15H2,1-4H3,(H,24,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 108 mg/mL (244.PMID:33234697 60 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC50s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC50s of 1.03 ± 0.57 μM and In Vivo:|Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD50 is >2000 mg/kg in mice and rats.|Products are for research use only. Not for human use.|