Product Name :
Dimemorfan phosphate
Description:
Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
CAS:
36304-84-4
Molecular Weight:
353.39
Formula:
C18H28NO4P
Chemical Name:
(1S,9S,10S)-4,17-dimethyl-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2,4,6-triene; phosphoric acid
Smiles :
CC1C=C2C(C[C@H]3[C@H]4CCCC[C@@]24CCN3C)=CC=1.OP(O)(O)=O
InChiKey:
ODJHDWLIOUGPPA-URVXVIKDSA-N
InChi :
InChI=1S/C18H25N.H3O4P/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2;1-5(2,3)4/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3;(H3,1,2,3,4)/t15-,17+,18+;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.|Product information|CAS Number: 36304-84-4|Molecular Weight: 353.39|Formula: C18H28NO4P|Chemical Name: (1S,9S,10S)-4,17-dimethyl-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2,4,6-triene; phosphoric acid|Smiles: CC1C=C2C(C[C@H]3[C@H]4CCCC[C@@]24CCN3C)=CC=1.Pyridostigmine manufacturer OP(O)(O)=O|InChiKey: ODJHDWLIOUGPPA-URVXVIKDSA-N|InChi: InChI=1S/C18H25N.H3O4P/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2;1-5(2,3)4/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3;(H3,1,2,3,4)/t15-,17+,18+;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 1 mg/mL (2.83 mM; Need ultrasonic). H2O : 20 mg/mL (56.59 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Alogliptin supplier |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Dimemorfan (5-20 μM) inhibits both fMLP- and PMA-induced ROS production in a concentration-dependent manner and is relatively more potent in inhibiting fMLP-induced ROS production with an IC50 value of 7.PMID:31643995 0 μM. Dimemorfan (10-50 μM) does not display significant activity in scavenging free radicals by xanthine/xanthine oxidase system. Dimemorfan significantly suppressed Mac-1 upregulation both in PMA- and fMLP-activated groups. Dimemorfan (10-20 μM) significantly suppresses LPS-induced ROS and NO production, and suppresses LPS-induced iNOS protein expression, and both the percentage of the positively stained population and the MCF intensities of MCP-1 and TNF-α in BV2 cytosol. Dimemorfan (20 μM) significantly blocks the degradation of cytosolic Iκ-Bα and nuclear translocation of NF-κB p65, as well as the transcriptional activity of NF-κB.|In Vivo:|Dimemorfan (6.25 or 12.5 mg/kg, s.c.) significantly attenuates the BAY k-8644-induced convulsive behaviors, in a dose-related manner (6.25 mg/kg dimemorfan+BAY k-8644 or 12.5 mg/kg dimemorfan+BAY k-8644 versus Saline+BAY k-8644, PProducts are for research use only. Not for human use.|