Product Name :
RIPGBM
Description:
RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).
CAS:
355406-76-7
Molecular Weight:
428.45
Formula:
C26H21FN2O3
Chemical Name:
N-(3-(Benzylamino)-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide
Smiles :
CC(=O)N(CC1C=CC(F)=CC=1)C1=C(NCC2C=CC=CC=2)C(=O)C2=CC=CC=C2C1=O
InChiKey:
COATXBHZYVUJQP-UHFFFAOYSA-N
InChi :
InChI=1S/C26H21FN2O3/c1-17(30)29(16-19-11-13-20(27)14-12-19)24-23(28-15-18-7-3-2-4-8-18)25(31)21-9-5-6-10-22(21)26(24)32/h2-14,28H,15-16H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).|Product information|CAS Number: 355406-76-7|Molecular Weight: 428.45|Formula: C26H21FN2O3|Chemical Name: N-(3-(Benzylamino)-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide|Smiles: CC(=O)N(CC1C=CC(F)=CC=1)C1=C(NCC2C=CC=CC=2)C(=O)C2=CC=CC=C2C1=O|InChiKey: COATXBHZYVUJQP-UHFFFAOYSA-N|InChi: InChI=1S/C26H21FN2O3/c1-17(30)29(16-19-11-13-20(27)14-12-19)24-23(28-15-18-7-3-2-4-8-18)25(31)21-9-5-6-10-22(21)26(24)32/h2-14,28H,15-16H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.BMVC Cancer |Shelf Life: ≥360 days if stored properly.Anti-Mouse IL-12 p40 Antibody (C17.8) Purity & Documentation |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33125298 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|RIPGBM causes caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 and acting as a molecular switch. It reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex .|References:|Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440.Products are for research use only. Not for human use.|