Product Name :
Piceatannol
Description:
Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa, L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects. In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide.
CAS:
10083-24-6
Molecular Weight:
244.24
Formula:
C14H12O4
Chemical Name:
4-[(E)-2-(3, 5-dihydroxyphenyl)ethenyl]benzene-1, 2-diol
Smiles :
OC1=CC=C(C=C1O)/C=C/C1C=C(O)C=C(O)C=1
InChiKey:
CDRPUGZCRXZLFL-OWOJBTEDSA-N
InChi :
InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Dorzagliatin} site|{Dorzagliatin} Metabolic Enzyme/Protease|{Dorzagliatin} Purity & Documentation|{Dorzagliatin} In Vivo|{Dorzagliatin} custom synthesis|{Dorzagliatin} Cancer}
Additional information:
Piceatannol is a selective inhibitor of protein tyrosine kinase Syk.{{Foscarbidopa} web|{Foscarbidopa} Neuronal Signaling|{Foscarbidopa} Protocol|{Foscarbidopa} In Vitro|{Foscarbidopa} supplier|{Foscarbidopa} Autophagy} It could inhibit ICa, L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1.PMID:33105316 Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects. In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide.|Product information|CAS Number: 10083-24-6|Molecular Weight: 244.24|Formula: C14H12O4|Synonym:|Astringenin|trans-Piceatannol|Chemical Name: 4-[(E)-2-(3, 5-dihydroxyphenyl)ethenyl]benzene-1, 2-diol|Smiles: OC1=CC=C(C=C1O)/C=C/C1C=C(O)C=C(O)C=1|InChiKey: CDRPUGZCRXZLFL-OWOJBTEDSA-N|InChi: InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 31 mg/mL (126.92 mM) H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7.Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.Products are for research use only. Not for human use.|