Product Name :
Lei-Dab7
Description:
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a Kd of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels.
CAS:
1061556-49-7
Molecular Weight:
3392.06
Formula:
C141H236N46O39S6
Chemical Name:
3-[7-({1-[(5-amino-1-{[1-carbamoyl-2-(1H-imidazol-5-yl)ethyl]carbamoyl}pentyl)carbamoyl]-2-methylpropyl}carbamoyl)-36,66-bis(4-aminobutyl)-56-(2-aminoethyl)-44-[2-(2-aminopropanamido)-3-phenylpropanamido]-75-(butan-2-yl)-15,53-bis(3-carbamimidamidopropyl)-80-(2-carbamoylethyl)-47-(carbamoylmethyl)-69-(carboxymethyl)-18,86-bis(hydroxymethyl)-21,27,30,50,83-pentakis(2-methylpropyl)-2,5,13,16,19,22,25,28,31,34,37,45,48,51,54,57,65,68,71,74,77,78,81,84,87-pentacosaoxo-9,10,41,42,61,62-hexathia-3,6,14,17,20,23,26,29,32,35,38,46,49,52,55,58,64,67,70,73,76,79,82,85,88-pentacosaazatricyclo[37.24.14.11¹²,⁵⁹]octaoctacontan-4-yl]propanoic acid
Smiles :
CCC(C)C1NC(=O)C2CSSCC(NC(=O)C(CC3C=CC=CC=3)NC(=O)C(C)N)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCN)C(=O)NC3CSSCC(NC(=O)C(CCCCN)NC(=O)C(CC(O)=O)NC(=O)CNC1=O)C(=O)NC(CCC(O)=O)C(=O)NC(CSSCC(NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC3=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)N2)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC1=CN=CN1)C(N)=O
InChiKey:
WEAKAAPTOACABK-UHFFFAOYSA-N
InChi :
InChI=1S/C141H236N46O39S6/c1-16-74(14)111-138(225)159-58-107(194)163-94(54-109(197)198)129(216)164-79(31-21-24-41-143)120(207)180-97-61-227-228-62-98-133(220)167-83(35-37-103(147)190)121(208)175-91(50-72(10)11)126(213)179-96(60-189)131(218)185-99(63-229-231-65-101(183-122(209)84(168-134(97)221)36-38-108(195)196)136(223)186-110(73(12)13)139(226)170-80(32-22-25-42-144)118(205)171-86(112(149)199)52-77-55-154-67-160-77)132(219)166-82(34-27-45-156-141(152)153)119(206)178-95(59-188)130(217)174-88(47-69(4)5)115(202)158-57-106(193)162-89(48-70(6)7)124(211)173-87(46-68(2)3)114(201)157-56-105(192)161-78(30-20-23-40-142)116(203)182-102(137(224)187-111)66-232-230-64-100(184-127(214)92(172-113(200)75(15)146)51-76-28-18-17-19-29-76)135(222)177-93(53-104(148)191)128(215)176-90(49-71(8)9)125(212)165-81(33-26-44-155-140(150)151)117(204)169-85(39-43-145)123(210)181-98/h17-19,28-29,55,67-75,78-102,110-111,188-189H,16,20-27,30-54,56-66,142-146H2,1-15H3,(H2,147,190)(H2,148,191)(H2,149,199)(H,154,160)(H,157,201)(H,158,202)(H,159,225)(H,161,192)(H,162,193)(H,163,194)(H,164,216)(H,165,212)(H,166,219)(H,167,220)(H,168,221)(H,169,204)(H,170,226)(H,171,205)(H,172,200)(H,173,211)(H,174,217)(H,175,208)(H,176,215)(H,177,222)(H,178,206)(H,179,213)(H,180,207)(H,181,210)(H,182,203)(H,183,209)(H,184,214)(H,185,218)(H,186,223)(H,187,224)(H,195,196)(H,197,198)(H4,150,151,155)(H4,152,153,156)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a Kd of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels.|Product information|CAS Number: 1061556-49-7|Molecular Weight: 3392.06|Formula: C141H236N46O39S6|Chemical Name: 3-[7-({1-[(5-amino-1-{[1-carbamoyl-2-(1H-imidazol-5-yl)ethyl]carbamoyl}pentyl)carbamoyl]-2-methylpropyl}carbamoyl)-36,66-bis(4-aminobutyl)-56-(2-aminoethyl)-44-[2-(2-aminopropanamido)-3-phenylpropanamido]-75-(butan-2-yl)-15,53-bis(3-carbamimidamidopropyl)-80-(2-carbamoylethyl)-47-(carbamoylmethyl)-69-(carboxymethyl)-18,86-bis(hydroxymethyl)-21,27,30,50,83-pentakis(2-methylpropyl)-2,5,13,16,19,22,25,28,31,34,37,45,48,51,54,57,65,68,71,74,77,78,81,84,87-pentacosaoxo-9,10,41,42,61,62-hexathia-3,6,14,17,20,23,26,29,32,35,38,46,49,52,55,58,64,67,70,73,76,79,82,85,88-pentacosaazatricyclo[37.24.14.11¹²,⁵⁹]octaoctacontan-4-yl]propanoic acid|Smiles: CCC(C)C1NC(=O)C2CSSCC(NC(=O)C(CC3C=CC=CC=3)NC(=O)C(C)N)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCN)C(=O)NC3CSSCC(NC(=O)C(CCCCN)NC(=O)C(CC(O)=O)NC(=O)CNC1=O)C(=O)NC(CCC(O)=O)C(=O)NC(CSSCC(NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC3=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)N2)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC1=CN=CN1)C(N)=O|InChiKey: WEAKAAPTOACABK-UHFFFAOYSA-N|InChi: InChI=1S/C141H236N46O39S6/c1-16-74(14)111-138(225)159-58-107(194)163-94(54-109(197)198)129(216)164-79(31-21-24-41-143)120(207)180-97-61-227-228-62-98-133(220)167-83(35-37-103(147)190)121(208)175-91(50-72(10)11)126(213)179-96(60-189)131(218)185-99(63-229-231-65-101(183-122(209)84(168-134(97)221)36-38-108(195)196)136(223)186-110(73(12)13)139(226)170-80(32-22-25-42-144)118(205)171-86(112(149)199)52-77-55-154-67-160-77)132(219)166-82(34-27-45-156-141(152)153)119(206)178-95(59-188)130(217)174-88(47-69(4)5)115(202)158-57-106(193)162-89(48-70(6)7)124(211)173-87(46-68(2)3)114(201)157-56-105(192)161-78(30-20-23-40-142)116(203)182-102(137(224)187-111)66-232-230-64-100(184-127(214)92(172-113(200)75(15)146)51-76-28-18-17-19-29-76)135(222)177-93(53-104(148)191)128(215)176-90(49-71(8)9)125(212)165-81(33-26-44-155-140(150)151)117(204)169-85(39-43-145)123(210)181-98/h17-19,28-29,55,67-75,78-102,110-111,188-189H,16,20-27,30-54,56-66,142-146H2,1-15H3,(H2,147,190)(H2,148,191)(H2,149,199)(H,154,160)(H,157,201)(H,158,202)(H,159,225)(H,161,192)(H,162,193)(H,163,194)(H,164,216)(H,165,212)(H,166,219)(H,167,220)(H,168,221)(H,169,204)(H,170,226)(H,171,205)(H,172,200)(H,173,211)(H,174,217)(H,175,208)(H,176,215)(H,177,222)(H,178,206)(H,179,213)(H,180,207)(H,181,210)(H,182,203)(H,183,209)(H,184,214)(H,185,218)(H,186,223)(H,187,224)(H,195,196)(H,197,198)(H4,150,151,155)(H4,152,153,156)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dobutamine} site|{Dobutamine} Adrenergic Receptor|{Dobutamine} Protocol|{Dobutamine} Formula|{Dobutamine} supplier|{Dobutamine} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Omalizumab} medchemexpress|{Omalizumab} Purity & Documentation|{Omalizumab} In stock|{Omalizumab} manufacturer|{Omalizumab} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32180538 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Intracerebroventricular (9-5 ng) injections of Lei-Dab7 decreases locomotor activity, food intake and body weight in rats deprived of food. A dose of 3 ng Lei-Dab7 has no effect on these types of behavior.|Products are for research use only. Not for human use.|