Product Name :
Desmethyl-QCA276
Description:
Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM.
CAS:
2126819-55-2
Molecular Weight:
387.46
Formula:
C21H17N5OS
Chemical Name:
5-benzyl-13-methyl-4-[2-(1H-pyrazol-4-yl)ethynyl]-8-oxa-3-thia-1,11,12-triazatricyclo[8.3.0.0²,⁶]trideca-2(6),4,10,12-tetraene
Smiles :
CC1=NN=C2COCC3=C(SC(C#CC4=CNN=C4)=C3CC3C=CC=CC=3)N21
InChiKey:
ZTDJXVBUQNJGQF-UHFFFAOYSA-N
InChi :
InChI=1S/C21H17N5OS/c1-14-24-25-20-13-27-12-18-17(9-15-5-3-2-4-6-15)19(28-21(18)26(14)20)8-7-16-10-22-23-11-16/h2-6,10-11H,9,12-13H2,1H3,(H,22,23)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Droxidopa} medchemexpress|{Droxidopa} GPCR/G Protein|{Droxidopa} Technical Information|{Droxidopa} Data Sheet|{Droxidopa} custom synthesis|{Droxidopa} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Enrofloxacin} MedChemExpress|{Enrofloxacin} Anti-infection|{Enrofloxacin} Technical Information|{Enrofloxacin} In Vitro|{Enrofloxacin} manufacturer|{Enrofloxacin} Cancer}
Additional information:
Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET.PMID:31992031 QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM.|Product information|CAS Number: 2126819-55-2|Molecular Weight: 387.46|Formula: C21H17N5OS|Chemical Name: 5-benzyl-13-methyl-4-[2-(1H-pyrazol-4-yl)ethynyl]-8-oxa-3-thia-1,11,12-triazatricyclo[8.3.0.0²,⁶]trideca-2(6),4,10,12-tetraene|Smiles: CC1=NN=C2COCC3=C(SC(C#CC4=CNN=C4)=C3CC3C=CC=CC=3)N21|InChiKey: ZTDJXVBUQNJGQF-UHFFFAOYSA-N|InChi: InChI=1S/C21H17N5OS/c1-14-24-25-20-13-27-12-18-17(9-15-5-3-2-4-6-15)19(28-21(18)26(14)20)8-7-16-10-22-23-11-16/h2-6,10-11H,9,12-13H2,1H3,(H,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|