Product Name :
CPUY074020
Description:
CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity.
CAS:
902279-44-1
Molecular Weight:
416.52
Formula:
C25H28N4O2
Chemical Name:
12-(piperidin-1-yl)-10-{[2-(pyrrolidin-1-yl)ethyl]amino}-15-oxa-14-azatetracyclo[7.6.1.0²,⁷.0¹³,¹⁶]hexadeca-1(16),2,4,6,9,11,13-heptaen-8-one
Smiles :
O=C1C2C3C(=NOC=3C3=CC=CC=C31)C(=CC=2NCCN1CCCC1)N1CCCCC1
InChiKey:
MMSYVEFXRAMWBA-UHFFFAOYSA-N
InChi :
InChI=1S/C25H28N4O2/c30-24-17-8-2-3-9-18(17)25-22-21(24)19(26-10-15-28-11-6-7-12-28)16-20(23(22)27-31-25)29-13-4-1-5-14-29/h2-3,8-9,16,26H,1,4-7,10-15H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity.|Product information|CAS Number: 902279-44-1|Molecular Weight: 416.52|Formula: C25H28N4O2|Chemical Name: 12-(piperidin-1-yl)-10-{[2-(pyrrolidin-1-yl)ethyl]amino}-15-oxa-14-azatetracyclo[7.6.{{Pindolol} web|{Pindolol} Adrenergic Receptor|{Pindolol} Protocol|{Pindolol} Purity|{Pindolol} custom synthesis|{Pindolol} Autophagy} 1.{{Glecaprevir} MedChemExpress|{Glecaprevir} HCV Protease|{Glecaprevir} Purity & Documentation|{Glecaprevir} References|{Glecaprevir} custom synthesis|{Glecaprevir} Autophagy} 0²,⁷.PMID:32449873 0¹³,¹⁶]hexadeca-1(16),2,4,6,9,11,13-heptaen-8-one|Smiles: O=C1C2C3C(=NOC=3C3=CC=CC=C31)C(=CC=2NCCN1CCCC1)N1CCCCC1|InChiKey: MMSYVEFXRAMWBA-UHFFFAOYSA-N|InChi: InChI=1S/C25H28N4O2/c30-24-17-8-2-3-9-18(17)25-22-21(24)19(26-10-15-28-11-6-7-12-28)16-20(23(22)27-31-25)29-13-4-1-5-14-29/h2-3,8-9,16,26H,1,4-7,10-15H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis. CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation.|In Vivo:|CPUY074020 exhibits reasonable PK properties, with an oral bioavailability of 55.5% and a T1/2 value of 4.0 hours at an oral dose of 10 mg/kg.|Products are for research use only. Not for human use.|